Despite
earlier indications that people have statins to lower cholesterol have
a lower risk of developing melanoma, a study of thousands of women
found that the popular drug to prevent the deadly skin cancer, nothing
to do.
The
cell experiments, and a test in people have suggested some of the very
properties of statins, which may protect against heart disease also
help prevent melanoma, the deadliest form of skin cancer.
However, the researchers found by Michael Simon, Karmanos Cancer Institute in Detroit, took no effect on melanoma among women who took drugs, including atorvastatin and pravastatin for lowering cholesterol.
"I do not think there's nothing here suggests that statins may protect malignant melanoma," said Simon.
The researchers, whose report was published in the journal Cancer, were data from the massive Women's Health Initiative study, which followed 120,000 women over 10 years.
The researchers compared more than 8,800 white women who took a statin that 111 000 women who know and have found 89 cases of melanoma among statin users and 1111 cases among non-users over a period of 12 years. This led to similar rates of melanoma in each group, nine cases per year per 10,000 women. The results were the same, irrespective of the nature of the women were taking statins how long it took. "For primary prevention (melanoma)` I think it put the nail in the coffin of this theory, "said Robert Della Valle, chief of dermatology at the VA Medical Center in Denver, who has not participated in the survey. The team `s Simon wrote that statins, because there is evidence that skin cells in the lab, it's possible that people who don` t take sufficient concentrations of active ingredients to achieve Unlike a risk of developing melanoma.
Other studies of people with an increased risk of melanoma than the general group of women in the current study could also "give more conclusive results," they added. Based on the evidence that statins can help destroy tumor cells in a petri dish, which diagnosed a way to drugs already in human use could be a melanoma, said Della Valle.
But as far as prevention goes, Simon said, it would be better for resources to things that are known to prevent skin cancer to be devoted to. Risk factors for melanoma is exposure to ultraviolet rays of the sun or tanning beds, fair skin to burn, moles or other pigmented birthmarks, smoking and family history of cancer prone. "I think, on the basis of (the results of the study), we must combine our forces to continue education on sun protection: Keep yourself out of use of the noon sun, sun protection," said Simon.
However, the researchers found by Michael Simon, Karmanos Cancer Institute in Detroit, took no effect on melanoma among women who took drugs, including atorvastatin and pravastatin for lowering cholesterol.
"I do not think there's nothing here suggests that statins may protect malignant melanoma," said Simon.
The researchers, whose report was published in the journal Cancer, were data from the massive Women's Health Initiative study, which followed 120,000 women over 10 years.
The researchers compared more than 8,800 white women who took a statin that 111 000 women who know and have found 89 cases of melanoma among statin users and 1111 cases among non-users over a period of 12 years. This led to similar rates of melanoma in each group, nine cases per year per 10,000 women. The results were the same, irrespective of the nature of the women were taking statins how long it took. "For primary prevention (melanoma)` I think it put the nail in the coffin of this theory, "said Robert Della Valle, chief of dermatology at the VA Medical Center in Denver, who has not participated in the survey. The team `s Simon wrote that statins, because there is evidence that skin cells in the lab, it's possible that people who don` t take sufficient concentrations of active ingredients to achieve Unlike a risk of developing melanoma.
Other studies of people with an increased risk of melanoma than the general group of women in the current study could also "give more conclusive results," they added. Based on the evidence that statins can help destroy tumor cells in a petri dish, which diagnosed a way to drugs already in human use could be a melanoma, said Della Valle.
But as far as prevention goes, Simon said, it would be better for resources to things that are known to prevent skin cancer to be devoted to. Risk factors for melanoma is exposure to ultraviolet rays of the sun or tanning beds, fair skin to burn, moles or other pigmented birthmarks, smoking and family history of cancer prone. "I think, on the basis of (the results of the study), we must combine our forces to continue education on sun protection: Keep yourself out of use of the noon sun, sun protection," said Simon.
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